|
KMID : 1189420040170030033
|
|
Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2004 Volume.17 No. 3 p.33 ~ p.37
|
|
|
Susceptibility of Oral Bacterial to Sophoraflavanone G isolated from the Root of Sophora flavescens
|
|
Kim Kyong-Heon
Kim Baek-Cheol
Yun Ju-Bong
Jeong Seung-Il
Kim Hong-Jun
Ju Young-Sung
|
|
|
Abstract
|
|
|
Objective: The aim of this work is to investigate the antibacterial activity of the Sohporaflavanone G isolated from Sophora flavescens (S. flavescens), as the development of microbial resistance to antibiotics make it essential to constantly look for new and active compounds effective against pathogenic bacteria.
Method : Sophoraflavanone G was isolated from the dried roots of Sophora flavescens Aiton (Leguminosae) by bioassay?guided fractionation. We investigated the effect of sophoraflavanone G on oral bacterial at various concentrations after incubation of 24 h in strains in the dose?dependent manner.
Results: The structure of active compound, Sophoraflavanone G having a lavandulyl group at C?8, was elucidated on the basis of spectral data especially 1H?NMR and I3C?NMR. The antimicrobial activity showed that Sophoraflavanone G exhibited antimicrobial activilies against all the bacteria tested (MICs, 0.39 - 6.25 ㎍／ml). Sophoraflavanone G showed the strong antimicrobial activity against all the facultative bacteria and microaerophilic bacteria (MICs, 0.78 - 1.56 ㎍／ml) and also Sophoraflavanone G showed the strong antimicrobial activity against obligate anaerobic bacteria (MICs, 0.39 - 6.25 ㎍／ml).
|
|
|
KEYWORD
|
|
|
S. flavescens , Antibacterial activity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|